5-Aminolevulinic acid biosynthesis in Propionibacterium shermanii and Halobacterium salinarium: Distribution of the two pathways of 5-aminolevulinic acid biosynthesis in prokaryotes.
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Glutamic Acid-l-semialdehyde, a Hypothetical Intermediate in the Biosynthesis of 5-Aminolevulinic Acid
W hether glutamate-l-sem ialdehyde (G -l-SA ) or 4,5 dioxovalerate (DOVA) is the intermedi ate between glutamate and A LA in the C-5 tetrapyrrol pathway is still a matter of controversy. Since no data characterizing G -l-SA are available it is not possible either to identify G -l-SA as intermediate or a precursor of ALA. Therefore, attem pts were made to establish a chemical synthesis of this ...
متن کامل5-Aminolevulinic acid promotes arachidonic acid biosynthesis in the red microalga Porphyridium purpureum
BACKGROUND The microalga Porphyridium purpureum within Rhodophyta abundantly produces several valuable proteins, polysaccharides, pigments and long-chain polyunsaturated fatty acid; it is especially effective in accumulating arachidonic acid (ARA). However, this high ARA yield is always achieved in conditions unfavourable for cell growth. In this study, we present a method for obtaining desirab...
متن کاملOptimization of the heme biosynthesis pathway for the production of 5-aminolevulinic acid in Escherichia coli
5-Aminolevulinic acid (ALA), the committed intermediate of the heme biosynthesis pathway, shows significant promise for cancer treatment. Here, we identified that in addition to hemA and hemL, hemB, hemD, hemF, hemG and hemH are also the major regulatory targets of the heme biosynthesis pathway. Interestingly, up-regulation of hemD and hemF benefited ALA accumulation whereas overexpression of h...
متن کاملBiosynthesis of 5-aminolevulinic acid and heme from 4,5-dioxovalerate in the rat.
We previously demonstrated an alternate pathway for the biosynthesis of 5-aminolevulinic acid (ALA) in bovine liver mitochondria and of tetrapyrroles in suspensions of rat hepatocytes (1980. J. Biol. Chem. 255: 3742; 1981. Proc. Natl. Acad. Sci. USA. 78: 5335). This pathway involves a transamination reaction that incorporates the intact 5-carbon skeleton of 4,5-dioxovaleric acid (DOVA) into ALA...
متن کامل5-Aminolevulinic acid synthesis in Escherichia coli.
A hemA mutant of Escherichia coli containing a multicopy plasmid which complemented the mutation excreted 5-aminolevulinic acid (ALA) into the medium. [1-14C]glutamate was substantially incorporated into ALA by this strain, whereas [2-14C]glycine was not. Periodate degradation of labeled ALA showed that C-5 of ALA was derived from C-1 of glutamate. The synthesis of ALA by two sonicate fractions...
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ژورنال
عنوان ژورنال: The Journal of General and Applied Microbiology
سال: 1993
ISSN: 1349-8037,0022-1260
DOI: 10.2323/jgam.39.513